Which body mass index is associated with the greatest survival?

Overweight and obesity are increasing worldwide. To help assess their relevance to mortality in different populations we meta-analysed prospective studies of body-mass index, limiting confounding and reverse causality by restricting analyses to never-smokers and excluding pre-existing disease and the first 5 years of follow-up. Of 10 625 411 participants in Asia, Australia and New Zealand, Europe, and […]

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Reductions in life expectancy with cardiometabolic disease

Cardiometabolic diseases often occur in one and the same individual. In this paper published in JAMA, we aimed to estimate by how much life expectancy is reduced in individuals suffering from cardiometabolic multimorbidity. In our analysis, we calculated mortality rates and hazard ratios (HRs) adjusted for age and sex using individual participant data from the […]

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Improving cardiovascular disease prediction with lipoprotein(a)

Lipoprotein(a) [Lp(a)] is a causal risk factor for cardiovascular disease. In this paper published in JACC we aimed to investigate whether Lp(a) modifies clinical risk assessment in the general community. We measured Lp(a) in 826 men and women (age range, 45 to 84 years) and recorded incidence of cardiovascular diseases over 15 years of follow-up. […]

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Leukocyte telomere length is linked to cardiovascular risk

Leading on from our work on telomeres in the Bruneck Study, we have conducted in this paper published in the BMJ a systematic review and meta-analysis to assess the association between leucocyte telomere length and cardiovascular risk. Our analysis included studies published up to March 2014 identified through searches of Medline, Web of Science, and […]

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Risk thresholds for alcohol consumption

  • October 2, 2019
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Recommendations about the limits for low risk for alcohol consumption vary substantially across different national guidelines. In this large collaborative paper published in the Lancet, we aimed to define thresholds associated with lowest risk for mortality and cardiovascular disease, by analysis of data from 599912 drinkers without previous cardiovascular disease. In our analysis, we combined […]

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NT-proBNP assessment improves prediction of cardiovascular events

  • October 4, 2018
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Current guidelines for primary prevention of cardiovascular diseases focus on the prediction of coronary heart disease and stroke. However, in a significant proportion of people, heart failure is the first presentation of cardiovascular disease, which is not included in prediction models. In this study published in Lancet Diabetes & Endocrinology, we aimed to test whether […]

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Frequent sauna bathing is associated with a lower risk of stroke

  • June 12, 2018
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Frequent sauna bathing is associated with a reduced risk of stroke, according to a new international study. In a 15-year follow-up study, people taking a sauna 4-7 times a week were 61% less likely to suffer a stroke than those taking a sauna once a week. This is the first prospective large-scale study on this […]

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