The Prospective Studies of Atherosclerosis consortium

71
Studies
105,131
Individuals
143
Scientists

Motivation

  • Atherosclerosis is a hardening and narrowing of the arteries which develops slowly and gradually and can cause cardiovascular diseases, such as heart attacks and strokes.
  • Atherosclerosis can be detected using a range of non-invasive imaging techniques even before any clinical symptoms occur (“subclinical atherosclerosis”).
  • A technique commonly used in clinical practice is the ultrasound of the neck arteries, which allows assessment of carotid intima-media thickness (cIMT) and characterisation of any atherosclerotic plaque.
  • Other techniques for detecting vessel wall pathology and dysfunction include flow-mediated dilatation, ankle-brachial index, and pulse-wave velocity.

The consortium

The Prospective Studies of Atherosclerosis (Proof-ATHERO) consortium collects world-wide data of epidemiological studies with atherosclerosis data. This unique collection of data allows us to study the development of atherosclerosis over life, better understand the influence of risk factors on atherosclerosis, and investigate clinical consequences of atherosclerosis.

Studies are eligible to join Proof-ATHERO, if they can provide:

  • repeat assessments of one or more measures of atherosclerosis;
  • detailed characterisation of study participants, including information on lifestyle, blood-based markers, and intake medication; and
  • clinical outcomes, in particular cardiovascular events.

Current funding

FWF Austrian Science Fund [Grant No. P 32488]

Dr. Johannes und Hertha TUBA-STIFTUNG

Proof-ATHERO Coordinating Centre

Principal investigator: Peter Willeit
Data management: Lena Tschiderer, Lisa Seekircher

Department of Neurology
Medical University of Innsbruck
Anichstraße 29/31, 1st floor
6020 Innsbruck
Austria

Studies

Proof-ATHERO involves studies in the general population, high-risk populations, and clinical trials.

List of studies

Proof-ATHERO projects

View the list of projects conducted within the Proof-ATHERO consortium.

Project pipeline

Contact

Get in contact with the coordinating centre

Contact us