Age at menopause and the risk of stroke

In this study, we investigated the relationship between age at menopause and different types of stroke in >200,000 postmenopausal women using data from the EPIC-CVD study and the UK Biobank. We obtained observational associations and performed Mendelian Randomisation analysis to study causality. We found a significant association between earlier menopause and higher risk of stroke including ischaemic stroke and intracerebral haemorrhage, but not subarachnoid haemorrhage. In the Mendelian Randomisation analysis, there was no statistically significant relationship between genetically proxied age at menopause and risk of any type of stroke, suggesting no causal link.

The full-text paper was published in the Journal of the American Heart Association.

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