Publications – Clinical Epidemiology

Disclaimer: The papers below are intended for private viewing by the page owner or those who otherwise have legitimate access to them. No part of it may in any form or by any electronic, mechanical, photocopying, recording, or any other means be reproduced, stored in a retrieval system or be broadcast or transmitted without the prior permission of the respective publishers. If your organization has a valid subscription of the journals, click on the DOI link for the legitimate copy of the papers.

Siller A, Seekircher L, Astl M, Tschiderer L, Wachter GA, Penz J, Pfeifer B, Huber A, Gaber M, Schennach H, Willeit P.

Anti-SARS-CoV-2 IgG Seroprevalence in Tyrol, Austria, among 28,768 Blood Donors between May 2022 and March 2023, Vaccines (Basel) 2024,12(3):284.

DOI: 10.3390/vaccines12030284

Seekircher L, Siller A, Amato M, Tschiderer L, Balog A, Astl M, Schennach H, Willeit P.

HemoCue Hb-801 Provides More Accurate Hemoglobin Assessment in Blood Donors Than OrSense NBM-200, Transfus Med Rev 2024,38(2):150826.

DOI: 10.1016/j.tmrv.2024.150826

Tschiderer L, van der Schouw YT, Burgess S, Bloemenkamp KWM, Seekircher L, Willeit P, Onland-Moret C, Peters SAE.

Hypertensive disorders of pregnancy and cardiovascular disease risk: a Mendelian randomisation study, Heart 2023,heartjnl-2023-323490.

DOI: 10.1136/heartjnl-2023-323490

Seekircher L, Tschiderer L, Lind L, Safarova MS, Kavousi M, Ikram MA, Lonn E, Yusuf S, Grobbee DE, Kastelein JJP, Visseren FLJ, Walters M, Dawson J, Higgins P, Agewall S, Catapano A, de Groot E, Espeland MA, Klingenschmid G, Magliano D, Olsen MH, Preiss D, Sander D, Skilton M, Zozulińska-Ziółkiewicz DA, Grooteman MPC, Blankestijn PJ, Kitagawa K, Okazaki S, Manzi MV, Mancusi C, Izzo R, Desvarieux M, Rundek T, Gerstein HC, Bots ML, Sweeting MJ, Lorenz MW, Willeit P.

Intima-media thickness at the near or far wall of the common carotid artery in cardiovascular risk assessment, Eur Heart J Open 2023,3(5):oead089.

DOI: 10.1093/ehjopen/oead089

Emerging Risk Factors Collaboration.

Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation, Lancet Diabetes Endocrinol 2023,11(10):731-742.

DOI: 10.1016/S2213-8587(23)00223-1

Tschiderer L, Peters SAE, van der Schouw YT, van Westing AC, Tong TYN, Willeit P, Seekircher L, Moreno-Iribas C, Huerta JM, Crous-Bou M, Söderholm M, Schulze MB, Johansson C, Själander S, Heath AK, Macciotta A, Dahm CC, Ibsen DB, Pala V, Mellemkjær L, Burgess S, Wood A, Kaaks R, Katzke V, Amiano P, Rodriguez-Barranco M, Engström G, Weiderpass E, Tjønneland A, Halkjær J, Panico S, Danesh J, Butterworth A, Onland-Moret NC.

Age at Menopause and the Risk of Stroke: Observational and Mendelian Randomization Analysis in 204 244 Postmenopausal Women, J Am Heart Assoc 2023,19;12(18):e030280.

DOI: 10.1161/JAHA.123.030280

Marini K, Seppi K, Kiechl S, Stockner H, Willeit P, Willeit J, Djamshidian A, Rungger G, Poewe W, Mahlknecht P.

Comparison of different risk scores for Parkinson disease in a population-based 10-year study, Eur J Neurol 2023,30(10):3347-3352.

DOI: 10.1111/ene.15971

Seekircher L, Bánki Z, Kimpel J, Rössler A, Schäfer H, Falkensammer B, Bante D, Forer L, Schönherr S; Shieldvacc-2 Study Group; Harthaller T, Sacher M, Ower C, Tschiderer L, Ulmer H, Krammer F, von Laer D, Borena W, Willeit P.

Immune response after two doses of the BNT162b2 COVID-19 vaccine and risk of SARS-CoV-2 breakthrough infection in Tyrol, Austria: an open-label, observational phase 4 trial, Lancet Microbe 2023,4(8):e612-e621.

DOI: 10.1016/S2666-5247(23)00107-6

Tschiderer L, Seekircher L, Izzo R, Mancusi C, Manzi MV, Baldassarre D, Amato M, Tremoli E, Veglia F, Tuomainen TP, Kauhanen J, Voutilainen A, Iglseder B, Lind L, Rundek T, Desvarieux M, Kato A, de Groot E, Aşçi G, Ok E, Agewall S, Beulens JWJ, Byrne CD, Calder PC, Gerstein HC, Gresele P, Klingenschmid G, Nagai M, Olsen MH, Parraga G, Safarova MS, Sattar N, Skilton M, Stehouwer CDA, Uthoff H, van Agtmael MA, van der Heijden AA, Zozulińska-Ziółkiewicz DA, Park HW, Lee MS, Bae JH, Beloqui O, Landecho MF, Plichart M, Ducimetiere P, Empana JP, Bokemark L, Bergström G, Schmidt C, Castelnuovo S, Calabresi L, Norata GD, Grigore L, Catapano A, Zhao D, Wang M, Liu J, Ikram MA, Kavousi M, Bots ML, Sweeting MJ, Lorenz MW, Willeit P; Proof‐ATHERO Study Group.

Association of Intima-Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque: Individual Participant Data Meta-Analysis of 20 Prospective Studies, J Am Heart Assoc 2023,20;12(12):e027657.

DOI: 10.1161/JAHA.122.027657

SCORE2-Diabetes Working Group and the ESC Cardiovascular Risk Collaboration.

SCORE2-Diabetes: 10-year cardiovascular risk estimation in type 2 diabetes in Europe, Eur Heart J 2023,21;44(28):2544-2556.

DOI: 10.1093/eurheartj/ehad260

Taleb A, Willeit P, Amir S, Perkmann T, Kozma MO, Watzenböck ML, Binder CJ, Witztum JL, Tsimikas S.

High immunoglobulin-M levels to oxidation-specific epitopes are associated with lower risk of acute myocardial infarction, J Lipid Res 2023,64(6):100391.

DOI: 10.1016/j.jlr.2023.100391

Feldman S, Gupta D, Navi BB, Grace Ho KW, Willeit P, Devlin S, Bolton KL, Arcila ME, Mantha S.

Tumor Genomic Profile Is Associated With Arterial Thromboembolism Risk in Patients With Solid Cancer, JACC CardioOncol 2023,18;5(2):246-255.

DOI: 10.1016/j.jaccao.2023.01.009

Laukkanen JA, Isiozor NM, Willeit P, Kunutsor SK.

Haemodynamic Gain Index Is Associated with Risk of Sudden Cardiac Death and Improves Risk Prediction: A Cohort Study, Cardiology 2023,148(3):246-256.

DOI: 10.1159/000530637. Epub 2023

NCD Risk Factor Collaboration (NCD-RisC).

Diminishing benefits of urban living for children and adolescents’ growth and development, Nature 2023,615(7954):874-883.

DOI: 10.1038/s41586-023-05772-8

Laukkanen JA, Isiozor NM, Willeit P, Kunutsor SK.

Hemodynamic Gain Index Is Associated With Cardiovascular Mortality and Improves Risk Prediction: A PROSPECTIVE COHORT STUDY, J Cardiopulm Rehabil Prev 2023,1;43(5):368-376.

DOI: 10.1097/HCR.0000000000000777

Tschiderer L, Seekircher L, Willeit P, Peters SAE.

Assessment of Cardiovascular Risk in Women: Progress so Far and Progress to Come, Int J Womens Health 2023,10;15:191-212.

DOI: 10.2147/IJWH.S364012

Moiseev S, Bulanov N, Crnogorac M, Direskeneli H, Galesic K, Gazel U, Geetha D, Guillevin L, Hrušková Z, Little MA, O'Neill L, Makarov E, McAdoo SP, Mohammad AJ, Moran S, Novikov P, Pusey CD, Rahmattulla C, Satrapová V, Silva J, Suvorov A, Tesar V, Terrier B, Willeit P, Zhao MH, Kronbichler A, Jayne DRW.

Traditional and Disease-Specific Risk Factors for Cardiovascular Events in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Multinational Retrospective Study, J Rheumatol 2023,50(9):1145-1151.

DOI: 10.3899/jrheum.220851

Joshi A, Schmidt LE, Burnap SA, Lu R, Chan MV, Armstrong PC, Baig F, Gutmann C, Willeit P, Santer P, Barwari T, Theofilatos K, Kiechl S, Willeit J, Warner TD, Mathur A, Mayr M.

Neutrophil-Derived Protein S100A8/A9 Alters the Platelet Proteome in Acute Myocardial Infarction and Is Associated With Changes in Platelet Reactivity, Arterioscler Thromb Vasc Biol 2023,42(1):49-62.

DOI: 10.1161/ATVBAHA.121.317113

Haider S, Smith L, Markovic L, Schuch FB, Sadarangani KP, Lopez Sanchez GF, Lopez-Bueno R, Gil-Salmerón A, Rieder A, Tully MA, Tschiderer L, Seekircher L, Willeit P, Grabovac I.

Associations between Physical Activity, Sitting Time, and Time Spent Outdoors with Mental Health during the First COVID-19 Lock Down in Austria, Int J Environ Res Public Health 2021,31;18(17):9168.

DOI: 10.3390/ijerph18179168

NCD Risk Factor Collaboration (NCD-RisC).

Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants, Lancet 2021,11;398(10304):957-980.

DOI: 10.1016/S0140-6736(21)01330-1

Willeit P, Bernar B, Zurl C, Al-Rawi M, Berghold A, Bernhard D, Borena W, Doppler C, Kerbl R, Köhler A, Krause R, Lamprecht B, Pröll J, Schmidt H, Steinmetz I, Stelzl E, Stoiber H, von Laer D, Zuber J, Müller T, Strenger V, Wagner M.

Sensitivity and specificity of the antigen-based anterior nasal self-testing programme for detecting SARS-CoV-2 infection in schools, Austria, March 2021, Euro Surveill 2021,26(34):2100797.

DOI: 10.2807/1560-7917.ES.2021.26.34.2100797

Willeit P, Krause R, Lamprecht B, Berghold A, Hanson B, Stelzl E, Stoiber H, Zuber J, Heinen R, Köhler A, Bernhard D, Borena W, Doppler C, von Laer D, Schmidt H, Pröll J, Steinmetz I, Wagner M.

Prevalence of RT-qPCR-detected SARS-CoV-2 infection at schools: First results from the Austrian School-SARS-CoV-2 prospective cohort study, Lancet Reg Health Eur 2021,5:100086.

DOI: 10.1016/j.lanepe.2021.100086

Priesemann V, Balling R, Bauer S, Beutels P, Valdez AC, Cuschieri S, Czypionka T, Dumpis U, Glaab E, Grill E, Hotulainen P, Iftekhar EN, Krutzinna J, Lionis C, Machado H, Martins C, McKee M, Pavlakis GN, Perc M, Petelos E, Pickersgill M, Prainsack B, Rocklöv J, Schernhammer E, Szczurek E, Tsiodras S, Van Gucht S, Willeit P.

Towards a European strategy to address the COVID-19 pandemic, Lancet 2021,4;398(10303):838-839.

DOI: 10.1016/S0140-6736(21)01808-0

Iftekhar EN, Priesemann V, Balling R, Bauer S, Beutels P, Calero Valdez A, Cuschieri S, Czypionka T, Dumpis U, Glaab E, Grill E, Hanson C, Hotulainen P, Klimek P, Kretzschmar M, Krüger T, Krutzinna J, Low N, Machado H, Martins C, McKee M, Mohr SB, Nassehi A, Perc M, Petelos E, Pickersgill M, Prainsack B, Rocklöv J, Schernhammer E, Staines A, Szczurek E, Tsiodras S, Van Gucht S, Willeit P.

A look into the future of the COVID-19 pandemic in Europe: an expert consultation, Lancet Reg Health Eur 2021,8:100185.

DOI: 10.1016/j.lanepe.2021.100185

SCORE2 working group and ESC Cardiovascular risk collaboration.

SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe, Eur Heart J 2021,1;42(25):2439-2454.

DOI: 10.1093/eurheartj/ehab309

Schuch FB, Bulzing RA, Meyer J, López-Sánchez GF, Grabovac I, Willeit P, Vancampfort D, Caperchione CM, Sadarangani KP, Werneck AO, Ward PB, Tully M, Smith L.

Moderate to vigorous physical activity and sedentary behavior changes in self-isolating adults during the COVID-19 pandemic in Brazil: a cross-sectional survey exploring correlates, Sport Sci Health 2022,18(1):155-163.

DOI: 10.1007/s11332-021-00788-x

Bergmann M, Tschiderer L, Stefani A, Heidbreder A, Willeit P, Högl B.

Sleep quality and daytime sleepiness in epilepsy: Systematic review and meta-analysis of 25 studies including 8,196 individuals, Sleep Med Rev 2021,57:101466.

DOI: 10.1016/j.smrv.2021.101466

Bettiol A, Sinico RA, Schiavon F, Monti S, Bozzolo EP, Franceschini F, Govoni M, Lunardi C, Guida G, Lopalco G, Paolazzi G, Vacca A, Gregorini G, Leccese P, Piga M, Conti F, Fraticelli P, Quartuccio L, Alberici F, Salvarani C, Bettio S, Negrini S, Selmi C, Sciascia S, Moroni G, Colla L, Manno C, Urban ML, Vannacci A, Pozzi MR, Fabbrini P, Polti S, Felicetti M, Marchi MR, Padoan R, Delvino P, Caporali R, Montecucco C, Dagna L, Cariddi A, Toniati P, Tamanini S, Furini F, Bortoluzzi A, Tinazzi E, Delfino L, Badiu I, Rolla G, Venerito V, Iannone F, Berti A, Bortolotti R, Racanelli V, Jeannin G, Padula A, Cauli A, Priori R, Gabrielli A, Bond M, Tedesco M, Pazzola G, Tomietto P, Pellecchio M, Marvisi C, Maritati F, Palmisano A, Dejaco C, Willeit J, Kiechl S, Olivotto I, Willeit P, Prisco D, Vaglio A, Emmi G; Italian EGPA Consortium.

Risk of acute arterial and venous thromboembolic events in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome), Eur Respir J 2021,6;57(5):2004158.

DOI: 10.1183/13993003.04158-2020

Marini K, Seppi K, Tschiderer L, Kiechl S, Stockner H, Willeit P, Willeit J, Djamshidian A, Rungger G, Poewe W, Mahlknecht P.

Application of the Updated Movement Disorder Society Criteria for Prodromal Parkinson’s Disease to a Population-Based 10-Year Study, Mov Disord 2021,36(6):1464-1466.

DOI: 10.1002/mds.28570

NCD Risk Factor Collaboration (NCD-RisC).

Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight, Elife 2021,9;10:e60060.

DOI: 10.7554/eLife.60060

Welsh P, Welsh C, Celis-Morales CA, Brown R, Ho FK, Ferguson LD, Mark PB, Lewsey J, Gray SR, Lyall DM, Gill JMR, Pell JP, de Lemos JA, Willeit P, Sattar N.

Lipoprotein(a) and cardiovascular disease: prediction, attributable risk fraction, and estimating benefits from novel interventions, Eur J Prev Cardiol 2022,9;28(18):1991-2000.

DOI: 10.1093/eurjpc/zwaa063

Rauchegger T, Angermann R, Willeit P, Schmid E, Teuchner B.

Two-year outcomes of minimally invasive XEN Gel Stent implantation in primary open-angle and pseudoexfoliation glaucoma, Acta Ophthalmol 2021,99(4):369-375.

DOI: 10.1111/aos.14627

Kunutsor SK, Laukkanen JA, Kauhanen J, Willeit P.

Physical activity may not be associated with long-term risk of dementia and Alzheimer’s disease, Eur J Clin Invest 2021,1(3):e13415.

DOI: 10.1111/eci.13415

Willeit P, Krause R, Lamprecht B, Berghold A, Hanson B, Stelzl E, Stoiber H, Zuber J, Heinen R, Koehler A, Bernhard D, Borena W, Doppler C, von Laer D, Schmidt H, Proell J, Steinmetz I, Wagner M

Prevalence of RT-PCR-detected SARS-CoV-2 infection at schools: First results from the Austrian School-SARS-CoV-2 Study, medrXiv 2021,[Pre-print]

DOI: 10.1101/2021.01.05.20248952

Tschiderer L, Klingenschmid G, Seekircher L, Willeit P

Carotid Intima-Media Thickness Predicts Carotid Plaque Development: Meta-analysis of Seven Studies Involving 9341 Participants, Eur J Clin Invest 2020,50(4):e13217.

DOI: 10.1111/eci.13217

Tschiderer L, Seekircher L, Klingenschmid G, Izzo R, Baldassarre D, Iglseder B, Calabresi L, Liu J, Price JF, Bae JH, Brouwers FP, de Groot E, Schmidt C, Bergström G, Aşçi G, Gresele P, Okazaki S, Kapellas K, Landecho MF, Sattar N, Agewall S, Zou ZY, Byrne CD, Nanayakkara PWB, Papagianni A, Witham MD, Bernal E, Ekart R, van Agtmael MA, Neves MF, Sato E, Ezhov M, Walters M, Olsen MH, Stolić R, Zozulińska-Ziółkiewicz DA, Hanefeld M, Staub D, Nagai M, Nieuwkerk PT, Huisman MV, Kato A, Honda H, Parraga G, Magliano D, Gabriel R, Rundek T, Espeland MA, Kiechl S, Willeit J, Lind L, Empana JP, Lonn E, Tuomainen TP, Catapano A, Chien KL, Sander D, Kavousi M, Beulens JWJ, Bots ML, Sweeting MJ, Lorenz MW, Willeit P

The Prospective Studies of Atherosclerosis (Proof-ATHERO) consortium: Design and rationale, Gerontology 2020,66(5):447-459.

DOI: 10.1159/000508498

Mahlknecht P, Stockner H, Marini K, Gasperi A, Djamshidian A, Willeit P, Kiechl S, Willeit J, Rungger G, Poewe W, Seppi K

Midbrain Hyperechogenicity, Hyposmia, Mild Parkinsonian Signs and Risk for Incident Parkinson’s Disease Over 10 Years: A Prospective Population-Based Study, Parkinsonism Relat Disord 2020,70:51-54.

DOI: 10.1016/j.parkreldis.2019.12.008

Klingenschmid G, Tschiderer L, Himmler G, Rungger G, Brugger S, Santer P, Willeit J, Kiechl S, Willeit P

Associations of Serum Dickkopf-1 and Sclerostin With Cardiovascular Events: Results From the Prospective Bruneck Study, J Am Heart Assoc 2020,9(6):e014816.

DOI: 10.1161/JAHA.119.014816

Chi X, Becker B, Yu Q, Willeit P, Jiao C, Huang L, Hossain MM, Grabovac I, Yeung A, Lin J, Veronese N, Wang J, Zhou X, Doig SR, Liu X, Carvalho AF, Yang L, Xiao T, Zou L, Fusar-Poli P, Solmi M

Prevalence and Psychosocial Correlates of Mental Health Outcomes Among Chinese College Students During the Coronavirus Disease (COVID-19) Pandemic, Front Psychiatry 2020,11:803.

DOI: 10.3389/fpsyt.2020.00803

Bahls M, Lorenz MW, Dörr M, Gao L, Kitagawa K, Tuomainen TP, Agewall S, Berenson G, Catapano AL, Norata GD, Bots ML, van Gilst W, Asselbergs FW, Brouwers FP, Uthoff H, Sander D, Poppert H, Hecht Olsen M, Empana JP, Schminke U, Baldassarre D, Veglia F, Franco OH, Kavousi M, de Groot E, Mathiesen EB, Grigore L, Polak JF, Rundek T, Stehouwer CD, Skilton MR, Hatzitolios AI, Savopoulos C, Ntaios G, Plichart M, McLachlan S, Lind L, Willeit P, Steinmetz H, Desvarieux M, Ikram MA, Johnsen SH, Schmidt C, Willeit J, Ducimetiere P, Price JF, Bergström G, Kauhanen J, Kiechl S, Sitzer M, Bickel H, Sacco RL, Hofman A, Völzke H, Thompson SG

Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium, Eur J Prev Cardiol 2020,27(3):234-243.

DOI: 10.1177/2047487319877078

Laukkanen JA, Kunutsor SK, Yates T, Willeit P, Kujala UM, Khan H, Zaccardi F

Prognostic Relevance of Cardiorespiratory Fitness as Assessed by Submaximal Exercise Testing for All-Cause Mortality: A UK Biobank Prospective Study, Mayo Clin Proc 2020,95(5):867-878.

DOI: 10.1016/j.mayocp.2019.12.030

Marini K, Mahlknecht P, Tutzer F, Stockner H, Gasperi A, Djamshidian A, Willeit P, Kiechl S, Willeit J, Rungger G, Noyce AJ, Schrag A, Poewe W, Seppi K

Application of a Simple Parkinson’s Disease Risk Score in a Longitudinal Population-Based Cohort, Mov Disord 2020,35(9):1658-1662.

DOI: 10.1002/mds.28127

Willeit P, Tschiderer L, Allara E, Reuber K, Seekircher L, Gao L, Liao X, Lonn E, Gerstein HC, Yusuf S, Brouwers FP, Asselbergs FW, van Gilst W, Anderssen SA, Grobbee DE, Kastelein JJP, Visseren FLJ, Ntaios G, Hatzitolios AI, Savopoulos C, Nieuwkerk PT, Stroes E, Walters M, Higgins P, Dawson J, Gresele P, Guglielmini G, Migliacci R, Ezhov M, Safarova M, Balakhonova T, Sato E, Amaha M, Nakamura T, Kapellas K, Jamieson LM, Skilton M, Blumenthal JA, Hinderliter A, Sherwood A, Smith PJ, van Agtmael MA, Reiss P, van Vonderen MGA, Kiechl S, Klingenschmid G, Sitzer M, Stehouwer CDA, Uthoff H, Zou ZY, Cunha AR, Neves MF, Witham MD, Park HW, Lee MS, Bae JH, Bernal E, Wachtell K, Kjeldsen SE, Olsen MH, Preiss D, Sattar N, Beishuizen E, Huisman MV, Espeland MA, Schmidt C, Agewall S, Ok E, Aşçi G, de Groot E, Grooteman MPC, Blankestijn PJ, Bots ML, Sweeting MJ, Thompson SG, Lorenz MW

Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk: Meta-Analysis of 119 Clinical Trials Involving 100 667 Patients, Circulation 2020,142(7):621-642.

DOI: 10.1161/CIRCULATIONAHA.120.046361

NCD Risk Factor Collaboration (NCD-RisC)

Repositioning of the Global Epicentre of Non-Optimal Cholesterol, Nature 2020,582(7810):73-77.

DOI: 10.1038/s41586-020-2338-1

Willeit P, Toell T, Boehme C, Krebs S, Mayer L, Lang C, Seekircher L, Tschiderer L, Willeit K, Rumpold G, Schoenherr G, Griesmacher A, Ferrari J, Knoflach M, Lang W, Kiechl S, Willeit J

STROKE-CARD care to prevent cardiovascular events and improve quality of life after acute ischaemic stroke or TIA: A randomised clinical trial, EClinicalMedicine 2020,25:100476.

DOI: 10.1016/j.eclinm.2020.100476

Stock K, Nagrani R, Gande N, Bernar B, Staudt A, Willeit P, Geiger R, Knoflach M, Kiechl-Kohlendorfer U

Birth Weight and Weight Changes From Infancy to Early Childhood as Predictors of Body Mass Index in Adolescence, J Pediatr 2020,222:120-126.e3.

DOI: 10.1016/j.jpeds.2020.03.048

Schuch FB, Bulzing RA, Meyer J, Vancampfort D, Firth J, Stubbs B, Grabovac I, Willeit P, Tavares VDO, Calegaro VC, Deenik J, López-Sánchez GF, Veronese N, Caperchione CM, Sadarangani KP, Abufaraj M, Tully MA, Smith L

Associations of moderate to vigorous physical activity and sedentary behavior with depressive and anxiety symptoms in self-isolating people during the COVID-19 pandemic: A cross-sectional survey in Brazil, Psychiatry Res 2020,292:113339.

DOI: 10.1016/j.psychres.2020.113339

Mahlknecht P, Peball M, Mair K, Werkmann M, Nocker M, Wolf E, Eisner W, Bajaj S, Quirbach S, Peralta C, Eschlböck S, Wenning GK, Willeit P, Seppi K, Poewe W

Has Deep Brain Stimulation Changed the Very Long-Term Outcome of Parkinson’s Disease? A Controlled Longitudinal Study, Mov Disord Clin Pract 2020,7(7):782-787.

DOI: 10.1002/mdc3.13039

Rauchegger T, Angermann R, Willeit P, Schmid E, Teuchner B

Two-year outcomes of minimally invasive XEN Gel Stent implantation in primary open-angle and pseudoexfoliation glaucoma, Acta Ophthalmol 2020,

DOI: 10.1111/aos.14627

Kunutsor SK, Laukkanen JA, Kauhanen J, Willeit P

Physical activity may not be associated with long-term risk of dementia and Alzheimer’s disease, Eur J Clin Invest 2020,

DOI: 10.1111/eci.13415

Yeang C, Willeit P, Tsimikas S

The interconnection between lipoprotein(a), lipoprotein(a) cholesterol and true LDL-cholesterol in the diagnosis of familial hypercholesterolemia, Curr Opin Lipidol 2020,31(6):305-312.

DOI: 10.1097/MOL.0000000000000713

NCD Risk Factor Collaboration (NCD-RisC)

Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants, Lancet 2020,396(10261):1511-1524.

DOI: 10.1016/S0140-6736(20)31859-6

Sangiao-Alvarellos S, Theofilatos K, Barwari T, Gutmann C, Takov K, Singh B, Juiz-Valiña P, Varela-Rodríguez BM, Outeiriño-Blanco E, Duregotti E, Zampetaki A, Lunger L, Ebenbichler C, Tilg H, García-Brao MJ, Willeit P, Mena E, Kiechl S, Cordido F, Mayr M

Metabolic recovery after weight loss surgery is reflected in serum microRNAs, BMJ Open Diabetes Res Care 2020,8(2):e001441.

DOI: 10.1136/bmjdrc-2020-001441

Willeit P, Yeang C, Moriarty PM, Tschiderer L, Varvel SA, McConnell JP, Tsimikas S

Low-Density Lipoprotein Cholesterol Corrected for Lipoprotein(a) Cholesterol, Risk Thresholds, and Cardiovascular Events, J Am Heart Assoc 2020,9(23):e016318.

DOI: 10.1161/JAHA.119.016318

Zhang J, Zou L, Jiao C, Zhang M, Wang L, Song W, Yu Q, Grabovac I, Zhang Y, Willeit P, Yang L

Cognitive Benefits of Activity Engagement Among 12,093 Chinese Adults Aged Over 65 Years, Brain Sci 2020,10(12):E967.

DOI: 10.3390/brainsci10120967

Harshfield EL, Pennells L, Schwartz JE, Willeit P, Kaptoge S, Bell S, Shaffer JA, Bolton T, Spackman S, Wassertheil-Smoller S, Kee F, Amouyel P, Shea SJ, Kuller LH, Kauhanen J, van Zutphen EM, Blazer DG, Krumholz H, Nietert PJ, Kromhout D, Laughlin G, Berkman L, Wallace RB, Simons LA, Dennison EM, Barr ELM, Meyer HE, Wood AM, Danesh J, Di Angelantonio E, Davidson KW

Association Between Depressive Symptoms and Incident Cardiovascular Diseases, JAMA 2020,324(23):2396-2405.

DOI: 10.1001/jama.2020.23068

Boehme C, Toell T, Mayer L, Domig L, Pechlaner R, Willeit K, Tschiderer L, Seekircher L, Willeit P, Griesmacher A, Knoflach M, Willeit J, Kiechl S

The dimension of preventable stroke in a large representative patient cohort, Neurology 2019,93(23):e2121-e2132.

DOI: 10.1212/WNL.0000000000008573

Emerging Risk Factors Collaboration

Meta‐analysis of non‐linear exposure‐outcome relationships using individual participant data: A comparison of two methods, Stat Med 2019,38(3):326-338.

DOI: 10.1002/sim.7974

NCD Risk Factor Collaboration (NCD-RisC)

Rising rural body-mass index is the main driver of the global obesity epidemic in adults, Nature 2019,569(7755):260-264.

DOI: 10.1038/s41586-019-1171-x

Pennells L, Kaptoge S, Wood A, Sweeting M, Zhao X, White I, Burgess S, Willeit P, Bolton T, et al.

Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studies, Eur Heart J 2019,40(7):621-631.

DOI: 10.1093/eurheartj/ehy653

WHO CVD Risk Chart Working Group

World Health Organization cardiovascular disease risk charts: revised prediction models to estimate risk in 21 global regions, Lancet Glob Health 2019,7(10):e1332-e1345.

DOI: 10.1016/S2214-109X(19)30318-3

Gregson J, Kaptoge S, Bolton T, Pennells L, Willeit P, Burgess S, Bell S, et al.

Cardiovascular Risk Factors Associated With Venous Thromboembolism, JAMA Cardiol 2019,4(2):163-173.

DOI: 10.1001/jamacardio.2018.4537

Smith L, Luchini C, Demurtas J, Soysal P, Stubbs B, Hamer M, Nottegar A, Lawlor RT, Lopez-Sanchez GF, Firth J, Koyanagi A, Roberts J, Willeit P, Waldhoer T, Loosemore M, Abbs AD, Johnstone J, Yang L, Veronese N

Telomere length and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies, Ageing Res Rev 2019,51:1-10.

DOI: 10.1016/j.arr.2019.02.003

NCD Risk Factor Collaboration

National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries, Int J Epidemiol 2019,dyz099.

DOI: 10.1093/ije/dyz099

Lee E, Willeit P, Laukkanen T, Kunutsor SK, Zaccardi F, Khan H, Laukkanen JA

Acute effects of exercise and sauna as a single intervention on arterial compliance, Eur J Prev Cardiol 2019,2047487319855450.

DOI: 10.1177/2047487319855454

Bateson M, Aviv A, Bendix L, Benetos A, Ben-Shlomo Y, Bojesen SE, Cooper C, Cooper R, Deary IJ, Hägg S, Harris SE, Kark JD, Kronenberg F, Kuh D, Labat C, Martin-Ruiz CM, Meyer C, Nordestgaard BG, Penninx BWJH, Pepper GV, Révész D, Said MA, Starr JM, Syddall H, Thomson WM, van der Harst P, Whooley M, von Zglinicki T, Willeit P, Zhan Y, Nettle D

Smoking does not accelerate leucocyte telomere attrition: a meta-analysis of 18 longitudinal cohorts, R Soc Open Sci 2019,6(6):190420.

DOI: 10.1098/rsos.190420

Laukkanen T, Lipponen J, Kunutsor SK, Zaccardi F, Araújo CGS, Mäkikallio TH, Khan H, Willeit P, Lee E, Poikonen S, Tarvainen M, Laukkanen JA

Recovery from sauna bathing favorably modulates cardiac autonomic nervous system, Complement Ther Med 2019,45:190-197.

DOI: 10.1016/j.ctim.2019.06.011

Peball M, Mahlknecht P, Werkmann M, Marini K, Murr F, Herzmann H, Stockner H, de Marzi R, Heim B, Djamshidian A, Willeit P, Willeit J, Kiechl S, Valent D, Krismer F, Wenning GK, Nocker M, Mair K, Poewe W, Seppi K

Prevalence and Associated Factors of Sarcopenia and Frailty in Parkinson’s Disease: A Cross-Sectional Study, Gerontology 2019,65(3):216-228.

DOI: 10.1159/000492572

Toell T, Boehme C, Mayer L, Krebs S, Lang C, Willeit K, Prantl B, Knoflach M, Rumpold G, Schoenherr G, Griesmacher A, Willeit P, Ferrari J, Lang W, Kiechl S, Willeit J

Pragmatic trial of multifaceted intervention (STROKE-CARD care) to reduce cardiovascular risk and improve quality-of-life after ischaemic stroke and transient ischaemic attack -study protocol, BMC Neurol 2018,18(1):187.

DOI: 10.1186/s12883-018-1185-2

Tschiderer L, Klingenschmid G, Nagrani R, Willeit J, Laukkanen JA, Schett G, Kiechl S, Willeit P

Osteoprotegerin and Cardiovascular Events in High-Risk Populations: Meta-Analysis of 19 Prospective Studies Involving 27 450 Participants, J Am Heart Assoc 2018,7(16):e009012.

DOI: 10.1161/JAHA.118.009012

TELOMAAS group

Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies, Am J Clin Nutr 2018,108(3):453-475.

DOI: 10.1093/ajcn/nqy107

Laukkanen T, Kunutsor SK, Khan H, Willeit P, Zaccardi F, Laukkanen JA

Sauna bathing is associated with reduced cardiovascular mortality and improves risk prediction in men and women: a prospective cohort study, BMC Med 2018,16(1):219.

DOI: 10.1186/s12916-018-1198-0

Burgess S, Ference BA, Staley JR, Freitag DF, Mason AM, Nielsen SF, Willeit P, Young R, et al.

Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies: A Mendelian Randomization Analysis, JAMA Cardiol 2018,3(7):619-627.

DOI: 10.1001/jamacardio.2018.1470

Willeit P, Ridker PM, Nestel PJ, Simes J, Tonkin AM, Pedersen TR, Schwartz GG, Olsson AG, Colhoun HM, Kronenberg F, Drechsler C, Wanner C, Mora S, Lesogor A, Tsimikas S

Baseline and on-statin treatment lipoprotein(a) levels for prediction of cardiovascular events: individual patient-data meta-analysis of statin outcome trials, Lancet 2018,392(10155):1311-1320.

DOI: 10.1016/S0140-6736(18)31652-0

Mahlknecht P, Georgiev D, Akram H, Brugger F, Vinke S, Zrinzo L, Hariz M, Bhatia KP, Hariz GM, Willeit P, Rothwell JC, Foltynie T, Limousin P.

Parkinsonian signs in patients with cervical dystonia treated with pallidal deep brain stimulation, Brain 2018,141(10):3023-3034.

DOI: 10.1093/brain/awy217

Chowdhury R, Ramond A, O'Keeffe LM, Shahzad S, Kunutsor SK, Muka T, Gregson J, Willeit P, Warnakula S, Khan H, Chowdhury S, Gobin R, Franco OH, Di Angelantonio E.

Environmental toxic metal contaminants and risk of cardiovascular disease: systematic review and meta-analysis, BMJ 2018,362:k3310.

DOI: 10.1136/bmj.k3310

Kunutsor SK, Häkkinen A, Zaccardi F, Laukkanen T, Lee E, Willeit P, Khan H, Laukkanen JA

Short-term effects of Finnish sauna bathing on blood-based markers of cardiovascular function in non-naive sauna users, Heart Vessels 2018,33(12):1515-1524.

DOI: 10.1007/s00380-018-1202-9

Kiechl S, Pechlaner R, Willeit P, Notdurfter M, Paulweber B, Willeit K, Werner P, Ruckenstuhl C, Iglseder B, Weger S, Mairhofer B, Gartner M, Kedenko L, Chmelikova M, Stekovic S, Stuppner H, Oberhollenzer F, Kroemer G, Mayr M, Eisenberg T, Tilg H, Madeo F, Willeit J.

Higher spermidine intake is linked to lower mortality: a prospective population-based study, Am J Clin Nutr 2018,108(2):371-380.

DOI: 10.1093/ajcn/nqy102

Lee E, Laukkanen T, Kunutsor SK, Khan H, Willeit P, Zaccardi F, Laukkanen JA.

Sauna exposure leads to improved arterial compliance: Findings from a non-randomised experimental study, Eur J Prev Cardiol 2018,25(2):130-138.

DOI: 10.1177/2047487317737629

Laukkanen T, Kunutsor SK, Zaccardi F, Lee E, Willeit P, Khan H, Laukkanen JA.

Acute effects of sauna bathing on cardiovascular function, J Hum Hypertens 2018,32(2):129-138.

DOI: 10.1038/s41371-017-0008-z

Evans JDW, Dobbin SJH, Pettit SJ, Di Angelantonio E, Willeit P.

High-Sensitivity Cardiac Troponin and New-Onset Heart Failure: A Systematic Review and Meta-Analysis of 67,063 Patients With 4,165 Incident Heart Failure Events, JACC Heart Fail 2018,6(3):187-197.

DOI: 10.1016/j.jchf.2017.11.003

O'Keeffe LM, Ramond A, Oliver-Williams C, Willeit P, Paige E, Trotter P, Evans J, WadstrÃ¶m J, Nicholson M, Collett D, Di Angelantonio E.

Mid- and Long-Term Health Risks in Living Kidney Donors: A Systematic Review and Meta-analysis, Ann Intern Med 2018 ,168(4):276-284.

DOI: 10.7326/M17-1235

Mahlknecht P, Gasperi A, Djamshidian A, Kiechl S, Stockner H, Willeit P, Willeit J, Rungger G, Poewe W, Seppi K.

Performance of the Movement Disorders Society criteria for prodromal Parkinson’s disease: A population-based 10-year study, Mov Disord 2018,33(3):405-413.

DOI: 10.1002/mds.27281

NCD Risk Factor Collaboration (NCD-RisC)

Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants, Int J Epidemiol 2018 ,47(3):872-883.

DOI: 10.1093/ije/dyy016

Lorenz MW, Gao L, Ziegelbauer K, Norata GD, Empana JP, Schmidtmann I, Lin HJ, McLachlan S, Bokemark L, Ronkainen K, Amato M, Schminke U, Srinivasan SR, Lind L, Okazaki S, Stehouwer CDA, Willeit P, Polak JF, Steinmetz H, Sander D, Poppert H, Desvarieux M, et al.

Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk – Results from the PROG-IMT collaboration, PLoS One 2018,13(4):e0191172.

DOI: 10.1371/journal.pone.0191172

Wood AM, Kaptoge S, Butterworth AS, Willeit P, Warnakula S, Bolton T, Paige E, Paul DS, Sweeting M, Burgess S, Bell S, Astle W, Stevens D, Koulman A, Selmer RM, Verschuren WMM, Sato S, Njolstad I, Woodward M, Salomaa V, Nordestgaard BG, Yeap BB, et al.

Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599,912 current drinkers in 83 prospective studies, Lancet 2018,391(10129):1513-1523.

DOI: 10.1016/S0140-6736(18)30134-X

Kunutsor SK, Khan H, Zaccardi F, Laukkanen T, Willeit P, Laukkanen JA.

Sauna bathing reduces the risk of stroke in Finnish men and women: A prospective cohort study, Neurology 2018,90(22):e1937-e1944.

DOI: 10.1212/WNL.0000000000005606

NCD Risk Factor Collaboration (NCD-RisC)

Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants, Lancet 2017,389(10064):37-55.

DOI: 10.1016/S0140-6736(16)31919-5

Willeit P, Skroblin P, Moschen AR, Yin X, Kaudewitz D, Zampetaki A, Barwari T, Whitehead M, Ramirez CM, Goedeke L, Rotllan N, Bonora E, Hughes AD, Santer P, Fernandez-Hernando C, Tilg H, Willeit J, Kiechl S, Mayr M.

Circulating MicroRNA-122 Is Associated With the Risk of New-Onset Metabolic Syndrome and Type 2 Diabetes, Diabetes 2017,66(2):347-357.

DOI: 10.2337/db16-0731

Gregson JM, Freitag DF, Surendran P, Stitziel NO, Chowdhury R, Burgess S, Kaptoge S, Gao P, Staley JR, Willeit P, Nielsen SF, Caslake M, Trompet S, Polfus LM, Kuulasmaa K, Kontto J, Perola M, Blankenberg S, Veronesi G, Gianfagna F, Männistö S, Kimura A, et al.

Genetic invalidation of Lp-PLA(2) as a therapeutic target: Large-scale study of five functional Lp-PLA(2)-lowering alleles, Eur J Prev Cardiol 2017,24(5):492-504.

DOI: 10.1177/2047487316682186

Pechlaner R, Tsimikas S, Yin X, Willeit P, Baig F, Santer P, Oberhollenzer F, Egger G, Witztum JL, Alexander VJ, Willeit J, Kiechl S, Mayr M.

Very-Low-Density Lipoprotein-Associated Apolipoproteins Predict Cardiovascular Events and Are Lowered by Inhibition of APOC-III, J Am Coll Cardiol 2017,69(7):789-800.

DOI: 10.1016/j.jacc.2016.11.065

Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP, Kurian KM, Pooley KA, Eeles RA, Lee JE, Fang S, Chen WV, et al.

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study, JAMA Oncol 2017,3(5):636-651.

DOI: 10.1001/jamaoncol.2016.5945

Langley SR, Willeit K, Didangelos A, Matic LP, Skroblin P, Barallobre-Barreiro J, Lengquist M, Rungger G, Kapustin A, Kedenko L, Molenaar C, Lu R, Barwari T, Suna G, Yin X, Iglseder B, Paulweber B, Willeit P, Shalhoub J, Pasterkamp G, Davies AH, Monaco C, et al.

Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques, J Clin Invest 2017,127(4):1546-1560.

DOI: 10.1172/JCI86924

Paige E, Masconi KL, Tsimikas S, Kronenberg F, Santer P, Weger S, Willeit J, Kiechl S, Willeit P.

Lipoprotein(a) and incident type-2 diabetes: results from the prospective Bruneck study and a meta-analysis of published literature, Cardiovasc Diabetol 2017,16(1):38.

DOI: 10.1186/s12933-017-0520-z

Willeit K, Pechlaner R, Willeit P, Skroblin P, Paulweber B, Schernthaner C, Toell T, Egger G, Weger S, Oberhollenzer M, Kedenko L, Iglseder B, Bonora E, Schett G, Mayr M, Willeit J, Kiechl S.

Association Between Vascular Cell Adhesion Molecule 1 and Atrial Fibrillation, JAMA Cardiol 2017,2(5):516-523.

DOI: 10.1001/jamacardio.2017.0064

PROG-IMT study group

Automatic identification of variables in epidemiological datasets using logic regression, BMC Med Inform Decis Mak 2017,17(1):40.

DOI: 10.1186/s12911-017-0429-1

Paige E, Barrett J, Pennells L, Sweeting M, Willeit P, Di Angelantonio E, Gudnason V, Nordestgaard BG, Psaty BM, Goldbourt U, Best LG, Assmann G, Salonen JT, Nietert PJ, Verschuren WMM, Brunner EJ, Kronmal RA, Salomaa V, Bakker SJL, Dagenais GR, Sato S, Jansson JH, et al.

Use of Repeated Blood Pressure and Cholesterol Measurements to Improve Cardiovascular Disease Risk Prediction: An Individual-Participant-Data Meta-Analysis, Am J Epidemiol 2017,186(8):899-907.

DOI: 10.1093/aje/kwx149

Zaccardi F, Laukkanen T, Willeit P, Kunutsor SK, Kauhanen J, Laukkanen JA.

Sauna Bathing and Incident Hypertension: A Prospective Cohort Study, Am J Hypertens 2017,30(11):1120-1125.

DOI: 10.1093/ajh/hpx102

Willeit P, Welsh P, Evans JDW, Tschiderer L, Boachie C, Jukema JW, Ford I, Trompet S, Stott DJ, Kearney PM, Mooijaart SP, Kiechl S, Di Angelantonio E, Sattar N.

High-Sensitivity Cardiac Troponin Concentration and Risk of First-Ever Cardiovascular Outcomes in 154,052 Participants, J Am Coll Cardiol 2017,70(5):558-568.

DOI: 10.1016/j.jacc.2017.05.062

Tschiderer L, Willeit J, Schett G, Kiechl S, Willeit P.

Osteoprotegerin concentration and risk of cardiovascular outcomes in nine general population studies: Literature-based meta-analysis involving 26,442 participants, PLoS One 2017,12(8):e0183910.

DOI: 10.1371/journal.pone.0183910

NCD Risk Factor Collaboration (NCD-RisC)

Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults, Lancet 2017,390(10113):2627-2642.

DOI: 10.1016/S0140-6736(17)32129-3

Willeit P, Thompson SG, Agewall S, Bergström G, Bickel H, Catapano AL, Chien KL, de Groot E, Empana JP, Etgen T, Franco OH, Iglseder B, Johnsen SH, Kavousi M, Lind L, Liu J, Mathiesen EB, Norata GD, Olsen MH, Papagianni A, Poppert H, Price JF, et al.

Inflammatory markers and extent and progression of early atherosclerosis: Meta-analysis of individual-participant-data from 20 prospective studies of the PROG-IMT collaboration, Eur J Prev Cardiol 2016,23(2):194-205.

DOI: 10.1177/2047487314560664

Zampetaki A, Willeit P, Burr S, Yin X, Langley SR, Kiechl S, Klein R, Rossing P, Chaturvedi N, Mayr M.

Angiogenic microRNAs Linked to Incidence and Progression of Diabetic Retinopathy in Type 1 Diabetes, Diabetes 2016,65(1):216-27.

DOI: 10.2337/db15-0389

Laimer M, Melmer A, Lamina C, Raschenberger J, Adamovski P, Engl J, Ress C, Tschoner A, Gelsinger C, Mair L, Kiechl S, Willeit J, Willeit P, Stettler C, Tilg H, Kronenberg F, Ebenbichler C.

Telomere length increase after weight loss induced by bariatric surgery: results from a 10 year prospective study, Int J Obes (Lond) 2016,40(5):773-8.

DOI: 10.1038/ijo.2015.238

Kaudewitz D, Skroblin P, Bender LH, Barwari T, Willeit P, Pechlaner R, Sunderland NP, Willeit K, Morton AC, Armstrong PC, Chan MV, Lu R, Yin X, Gracio F, Dudek K, Langley SR, Zampetaki A, de Rinaldis E, Ye S, Warner TD, Saxena A, Kiechl S, et al.

Association of MicroRNAs and YRNAs With Platelet Function, Circ Res 2016,118(3):420-432.

DOI: 10.1161/CIRCRESAHA.114.305663

PROG-IMT study group

Normative values for carotid intima media thickness and its progression: Are they transferrable outside of their cohort of origin, Eur J Prev Cardiol 2016,23(11):1165-73.

DOI: 10.1177/2047487315625543

Willeit P, Skroblin P, Kiechl S, Fernandez-Hernando C, Mayr M.

Liver microRNAs: potential mediators and biomarkers for metabolic and cardiovascular disease?, Eur Heart J 2016,37(43):3260-3266.

Mahlknecht P, Gasperi A, Willeit P, Kiechl S, Stockner H, Willeit J, Rungger G, Sawires M, Nocker M, Rastner V, Mair KJ, Hotter A, Poewe W, Seppi K.

Prodromal Parkinson’s disease as defined per MDS research criteria in the general elderly community, Mov Disord 2016,31(9):1405-8.

DOI: 10.1002/mds.26674

Global BMI Mortality Collaboration

Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents, Lancet 2016,388(10046):776-86.

DOI: 10.1016/S0140-6736(16)30175-1

Barallobre-Barreiro J, Gupta SK, Zoccarato A, Kitazume-Taneike R, Fava M, Yin X, Werner T, Hirt MN, Zampetaki A, Viviano A, Chong M, Bern M, Kourliouros A, Domenech N, Willeit P, Shah AM, Jahangiri M, Schaefer L, Fischer JW, Iozzo RV, Viner R, Thum T, et al.

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation, Circulation 2016,134(11):817-32.

DOI: 10.1161/CIRCULATIONAHA.115.016423

Willeit P, Kaptoge S, Welsh P, Butterworth AS, et al.

Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis, Lancet Diabetes Endocrinol 2016,4(10):840-9.

DOI: 10.1016/S2213-8587(16)30196-6

Barban N, Jansen R, de Vlaming R, Vaez A, Mandemakers JJ, Tropf FC, Shen X, Wilson JF, Chasman DI, Nolte IM, Tragante V, van der Laan SW, Perry JR, Kong A; BIOS Consortium., Ahluwalia TS, Albrecht E, Yerges-Armstrong L, Atzmon G, Auro K, Ayers K, Bakshi A, et al.

Genome-wide analysis identifies 12 loci influencing human reproductive behavior, Nat Genet 2016,48(12):1462-1472.

DOI: 10.1038/ng.3698

Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, et al.

Cardioprotection and lifespan extension by the natural polyamine spermidine, Nat Med 2016,22(12):1428-1438.

DOI: 10.1038/nm.4222

Pechlaner R, Willeit P, Summerer M, Santer P, Egger G, Kronenberg F, Demetz E, Weiss G, Tsimikas S, Witztum JL, Willeit K, Iglseder B, Paulweber B, Kedenko L, Haun M, Meisinger C, Gieger C, Müller-Nurasyid M, Peters A, Willeit J, Kiechl S.

Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with progressive atherosclerosis and incident cardiovascular disease, Arterioscler Thromb Vasc Biol 2015,35(1):229-36.

DOI: 10.1161/ATVBAHA.114.304729

Willeit J, Geley T, Schöch J, Rinner H, Tür A, Kreuzer H, Thiemann N, Knoflach M, Toell T, Pechlaner R, Willeit K, Klingler N, Praxmarer S, Baubin M, Beck G, Berek K, Dengg C, Engelhardt K, Erlacher T, Fluckinger T, Grander W, Grossmann J, et al.

Thrombolysis and clinical outcome in patients with stroke after implementation of the Tyrol Stroke Pathway: a retrospective observational study, Lancet Neurol 2015,14(1):48-56.

DOI: 10.1016/S1474-4422(14)70286-8

Emerging Risk Factors Collaboration

Covariate-adjusted measures of discrimination for survival data, Biom J 2015,57(4):592-613.

DOI: 10.1002/bimj.201400061

Interleukin 1 Genetics Consortium

Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis, Lancet Diabetes Endocrinol 2015,3(4):243-53.

DOI: 10.1016/S2213-8587(15)00034-0

Zaccardi F, Pitocco D, Willeit P, Laukkanen JA.

Efficacy and safety of P2Y12 inhibitors according to diabetes, age, gender, body mass index and body weight: systematic review and meta-analyses of randomized clinical trials, Atherosclerosis 2015,240(2):439-45.

DOI: 10.1016/j.atherosclerosis.2015.04.015

Willeit P, Freitag DF, Laukkanen JA, Chowdhury S, Gobin R, Mayr M, Di Angelantonio E, Chowdhury R.

Asymmetric dimethylarginine and cardiovascular risk: systematic review and meta-analysis of 22 prospective studies, J Am Heart Assoc 2015,4(6):e001833.

DOI: 10.1161/JAHA.115.001833

Thompson SG, Willeit P.

UK Biobank comes of age, Lancet 2015,386(9993):509-10.

DOI: 10.1016/S0140-6736(15)60578-5

Di Angelantonio E, Kaptoge S, Wormser D, Willeit P, et al.

Association of Cardiometabolic Multimorbidity With Mortality, JAMA 2015,314(1):52-60.

DOI: 10.1001/jama.2015.7008

Lorenz MW, Price JF, Robertson C, Bots ML, Polak JF, Poppert H, Kavousi M, Dörr M, Stensland E, Ducimetiere P, Ronkainen K, Kiechl S, Sitzer M, Rundek T, Lind L, Liu J, Bergström G, Grigore L, Bokemark L, Friera A, Yanez D, Bickel H, et al.

Carotid intima-media thickness progression and risk of vascular events in people with diabetes: results from the PROG-IMT collaboration, Diabetes Care 2015,38(10):1921-9.

DOI: 10.2337/dc14-2732

Laukkanen JA, Willeit P, Kurl S, Mäkikallio TH, Savonen K, Ronkainen K, Rauramaa R.

Elevated systolic blood pressure during recovery from exercise and the risk of sudden cardiac death, J Hypertens 2014,32(3):659-66.

DOI: 10.1097/HJH.0000000000000066

Emerging Risk Factors Collaboration

Assessing risk prediction models using individual participant data from multiple studies, Am J Epidemiol 2014,179(5):621-32.

DOI: 10.1093/aje/kwt298

Stegemann C, Pechlaner R, Willeit P, Langley SR, Mangino M, Mayr U, Menni C, Moayyeri A, Santer P, Rungger G, Spector TD, Willeit J, Kiechl S, Mayr M.

Lipidomics profiling and risk of cardiovascular disease in the prospective population-based Bruneck study, Circulation 2014,129(18):1821-31.

DOI: 10.1161/CIRCULATIONAHA.113.002500

Di Angelantonio E, Gao P, Khan H, Butterworth AS, Wormser D, Kaptoge S, Kondapally Seshasai SR, Thompson A, Sarwar N, Willeit P, Ridker PM, Barr EL, Khaw KT, Psaty BM, Brenner H, Balkau B, Dekker JM, Lawlor DA, Daimon M, Willeit J, Njølstad I, et al.

Glycated hemoglobin measurement and prediction of cardiovascular disease, JAMA 2014,311(12):1225-33.

DOI: 10.1001/jama.2014.1873

Pechlaner R, Kiechl S, Willeit P, Demetz E, Haun M, Weger S, Oberhollenzer F, Kronenberg F, Bonora E, Weiss G, Willeit J.

Haptoglobin 2-2 genotype is not associated with cardiovascular risk in subjects with elevated glycohemoglobin-results from the Bruneck Study, J Am Heart Assoc 2014,3(3):e000732.

DOI: 10.1161/JAHA.113.000732

Cuello F, Shankar-Hari M, Mayr U, Yin X, Marshall M, Suna G, Willeit P, Langley SR, Jayawardhana T, Zeller T, Terblanche M, Shah AM, Mayr M.

Redox state of pentraxin 3 as a novel biomarker for resolution of inflammation and survival in sepsis, Mol Cell Proteomics 2014,13(10):2545-57.

DOI: 10.1074/mcp.M114.039446

Haycock PC, Heydon EE, Kaptoge S, Butterworth AS, Thompson A, Willeit P.

Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis, BMJ 2014,349:g4227.

DOI: 10.1136/bmj.g4227

Willeit P, Kiechl S, Kronenberg F, Witztum JL, Santer P, Mayr M, Xu Q, Mayr A, Willeit J, Tsimikas S.

Discrimination and net reclassification of cardiovascular risk with lipoprotein(a): prospective 15-year outcomes in the Bruneck Study, J Am Coll Cardiol 2014,64(9):851-60.

DOI: 10.1016/j.jacc.2014.03.061

Zampetaki A, Attia R, Mayr U, Gomes RS, Phinikaridou A, Yin X, Langley SR, Willeit P, Lu R, Fanshawe B, Fava M, Barallobre-Barreiro J, Molenaar C, So PW, Abbas A, Jahangiri M, Waltham M, Botnar R, Smith A, Mayr M.

Role of miR-195 in aortic aneurysmal disease, Circ Res 2014,115(10):857-66.

DOI: 10.1161/CIRCRESAHA.115.304361

Laukkanen JA, Khan H, Kurl S, Willeit P, Karppi J, Ronkainen K, Di Angelantonio E.

Left ventricular mass and the risk of sudden cardiac death: a population-based study, J Am Heart Assoc 2014,3(6):e001285.

DOI: 10.1161/JAHA.114.001285

Willeit P, Raschenberger J, Heydon EE, Tsimikas S, Haun M, Mayr A, Weger S, Witztum JL, Butterworth AS, Willeit J, Kronenberg F, Kiechl S.

Leucocyte telomere length and risk of type 2 diabetes mellitus: new prospective cohort study and literature-based meta-analysis, PLoS One 2014,9(11):e112483.

DOI: 10.1371/journal.pone.0112483

Welsh P, Doolin O, Willeit P, Packard C, Macfarlane P, Cobbe S, Gudnason V, Di Angelantonio E, Ford I, Sattar N.

N-terminal pro-B-type natriuretic peptide and the prediction of primary cardiovascular events: results from 15-year follow-up of WOSCOPS, Eur Heart J 2013,34(6):443-50.

DOI: 10.1093/eurheartj/ehs239

Davis D, Gregson J, Willeit P, Stephan B, Al-Shahi Salman R, Brayne C.

Patent foramen ovale, ischemic stroke and migraine: systematic review and stratified meta-analysis of association studies, Neuroepidemiology 2013,40(1):56-67.

DOI: 10.1159/000341924

Willeit P, Zampetaki A, Dudek K, Kaudewitz D, King A, Kirkby NS, Crosby-Nwaobi R, Prokopi M, Drozdov I, Langley SR, Sivaprasad S, Markus HS, Mitchell JA, Warner TD, Kiechl S, Mayr M.

Circulating microRNAs as novel biomarkers for platelet activation, Circ Res 2013,112(4):595-600.

DOI: 10.1161/CIRCRESAHA.111.300539

Mayr M, Zampetaki A, Willeit P, Willeit J, Kiechl S.

MicroRNAs within the continuum of postgenomics biomarker discovery, Arterioscler Thromb Vasc Biol 2013,33(2):206-14.

DOI: 10.1161/ATVBAHA.112.300141

Kiechl S, Wittmann J, Giaccari A, Knoflach M, Willeit P, Bozec A, Moschen AR, Muscogiuri G, Sorice GP, Kireva T, Summerer M, Wirtz S, Luther J, Mielenz D, Billmeier U, Egger G, Mayr A, Oberhollenzer F, Kronenberg F, Orthofer M, Penninger JM, Meigs JB, et al.

Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus, Nat Med 2013,19(3):358-63.

DOI: 10.1038/nm.3084

Willeit P, Thompson A, Aspelund T, Rumley A, Eiriksdottir G, Lowe G, Gudnason V, Di Angelantonio E.

Hemostatic factors and risk of coronary heart disease in general populations: new prospective study and updated meta-analyses, PLoS One 2013,8(2):e55175.

DOI: 10.1371/journal.pone.0055175

Kickingereder P, Willeit P, Simon T, Ruge MI.

Diagnostic value and safety of stereotactic biopsy for brainstem tumors: a systematic review and meta-analysis of 1480 cases, Neurosurgery 2013,72(6):873-81.

DOI: 10.1227/NEU.0b013e31828bf445

Kaudewitz D, Lee R, Willeit P, McGregor R, Markus HS, Kiechl S, Zampetaki A, Storey RF, Channon KM, Mayr M.

Impact of intravenous heparin on quantification of circulating microRNAs in patients with coronary artery disease, Thromb Haemost 2013,110(3):609-15.

DOI: 10.1160/TH13-05-0368

Zampetaki A, Willeit P, Drozdov I, Kiechl S, Mayr M.

Profiling of circulating microRNAs: from single biomarkers to re-wired networks, Cardiovasc Res 2012,93(4):555-62.

DOI: 10.1093/cvr/cvr266

Barallobre-Barreiro J, Didangelos A, Schoendube FA, Drozdov I, Yin X, FernÃ¡ndez-Caggiano M, Willeit P, Puntmann VO, Aldama-Lopez G, Shah AM, Domenech N, Mayr M.

Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury, Circulation 2012,125(6):789-802.

DOI: 10.1161/CIRCULATIONAHA.111.056952

Sarwar N, Butterworth AS, Freitag DF, Gregson J, Willeit P, Gorman DN, Gao P, Saleheen D, Rendon A, Nelson CP, Braund PS, Hall AS, Chasman DI, Tybjærg-Hansen A, Chambers JC, Benjamin EJ, Franks PW, Clarke R, Wilde AA, Trip MD, Steri M, et al.

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies, Lancet 2012,379(9822):1205-13.

DOI: 10.1016/S0140-6736(11)61931-4

Ruecker M, Matosevic B, Willeit P, Kirchmayr M, Zangerle A, Knoflach M, Willeit J, Kiechl S.

Subtherapeutic warfarin therapy entails an increased bleeding risk after stroke thrombolysis, Neurology 2012,79(1):31-8.

DOI: 10.1212/WNL.0b013e31825dcdf0

Emerging Risk Factors Collaboration

Lipid-related markers and cardiovascular disease prediction, JAMA 2012,307(23):2499-506.

DOI: 10.1001/jama.2012.6571

Zampetaki A, Willeit P, Tilling L, Drozdov I, Prokopi M, Renard JM, Mayr A, Weger S, Schett G, Shah A, Boulanger CM, Willeit J, Chowienczyk PJ, Kiechl S, Mayr M.

Prospective study on circulating MicroRNAs and risk of myocardial infarction, J Am Coll Cardiol 2012,60(4):290-9.

DOI: 10.1016/j.jacc.2012.03.056

Tsimikas S, Willeit P, Willeit J, Santer P, Mayr M, Xu Q, Mayr A, Witztum JL, Kiechl S.

Oxidation-specific biomarkers, prospective 15-year cardiovascular and stroke outcomes, and net reclassification of cardiovascular events, J Am Coll Cardiol 2012,60(21):2218-29.

DOI: 10.1016/j.jacc.2012.08.979

Ehrlenbach S, Willeit P, Kiechl S, Willeit J, Reindl M, Schanda K, Kronenberg F, Brandstätter A.

Influences on the reduction of relative telomere length over 10 years in the population-based Bruneck Study: introduction of a well-controlled high-throughput assay, Int J Epidemiol 2009,38(6):1725-34.

DOI: 10.1093/ije/dyp273

Ehrlenbach S, Willeit P, Kiechl S, Willeit J, Reindl M, Schanda K, Kronenberg F, Brandstätter A.

Raising the bar on telomere epidemiology, Int J Epidemiol 2010,39(1):308-9.

DOI: 10.1093/ije/dyp383

Willeit P, Willeit J, Brandstätter A, Ehrlenbach S, Mayr A, Gasperi A, Weger S, Oberhollenzer F, Reindl M, Kronenberg F, Kiechl S.

Cellular aging reflected by leukocyte telomere length predicts advanced atherosclerosis and cardiovascular disease risk, Arterioscler Thromb Vasc Biol 2010,30(8):1649-56.

DOI: 10.1161/ATVBAHA.110.205492

Willeit P, Willeit J, Mayr A, Weger S, Oberhollenzer F, Brandstätter A, Kronenberg F, Kiechl S.

Telomere length and risk of incident cancer and cancer mortality, JAMA 2010,304(1):69-75.

DOI: 10.1001/jama.2010.897

Zampetaki A, Kiechl S, Drozdov I, Willeit P, Mayr U, Prokopi M, Mayr A, Weger S, Oberhollenzer F, Bonora E, Shah A, Willeit J, Mayr M.

Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes, Circ Res 2010,107(6):810-7.

DOI: 10.1161/CIRCRESAHA.110.226357

Merki E, Graham M, Taleb A, Leibundgut G, Yang X, Miller ER, Fu W, Mullick AE, Lee R, Willeit P, Crooke RM, Witztum JL, Tsimikas S.

Antisense oligonucleotide lowers plasma levels of apolipoprotein (a) and lipoprotein (a) in transgenic mice, J Am Coll Cardiol 2011,57(15):1611-21.

DOI: 10.1016/j.jacc.2010.10.052

Willeit P, Willeit J, Kloss-Brandstätter A, Kronenberg F, Kiechl S.

Fifteen-year follow-up of association between telomere length and incident cancer and cancer mortality, JAMA 2011,306(1):42-4.

DOI: 10.1001/jama.2011.901