Principal investigators

The Lipoprotein(a) Studies Collaboration is jointly led by Peter Willeit (Medical University of Innsbruck) and Sotirios Tsimikas (University of Califonia-San Diego).

Key publication

The key publication from this collaboration has been published in the Lancet on 4 October 2018. Please click on the subsequent links to obtain full-text and a slide deck.

Full-text

This document gives you access to the manuscript version as accepted by the Lancet.

Click here to download

Slide deck

This document summarises the key results of our Lancet paper in a set of Powerpoint slides.

Click here to download

Rationale

  • Lipoprotein(a) [Lp(a)] is a lipoprotein composed of apolipoprotein(a) covalently bound to apolipoprotein B of a low-density lipoprotein-like particle.
  • Lp(a) is an established risk factor for cardiovascular disease. Lp(a) has pro-inflammatory and pro-thrombotic properties and may thereby promote the developement of atherosclerosis.
  • In contrast to other major lipoproteins, there is currently no approved specific therapy available to lower circulating plasma levels of Lp(a).

Overarching aim

Lipoprotein(a) Studies Collaboration (LPASC) has harmonised Lp(a) data from prospective cohort studies and clinical trials. The overarching aim of the consortium is to:

  • better understand the role of Lp(a) as a independent risk marker in the primary vs. secondary prevention setting,
  • characterise the effects of different medications on Lp(a) concentration, and
  • evaluate the usefulness of Lp(a) measurements in risk prediction models over and beyond information on conventional risk factors.

http://www.onlinejacc.org/content/64/9/851

Figure. CVD risk reclassification using Lp(a) information in the Bruneck Study. http://www.onlinejacc.org/content/64/9/851

Collaborating studies

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