CAMERA – Carotid Atherosclerosis – Metformin for Insulin Resistance Study

Study design

The Carotid Atherosclerosis – Metformin for Insulin Resistance Study (CAMERA) is a two-arm clinical trial based in Glasgow, Scotland. The principal aim of the trial was to investigate the effect of Metformin (2x 850mg/day) versus placebo on carotid artery atherosclerosis in non-diabetic individuals with coronary heart disease. Individuals were eligible for inclusion if they had proven coronary heart disease, had elevated waist circumference as per the International Diabetes Foundation criteria, and were taking statin. All participants provided written informed consent. The study was approved by the Medicines and Healthcare Products Regulatory Agency and West Glasgow Research Ethics Committee.

Link to study webpage – https://clinicaltrials.gov/ct2/show/NCT00723307 

Key publications

Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial. Lancet Diabetes Endocrinol. 2014 Feb;2(2):116-24