SECURE – Study to Evaluate Carotid Ultrasound Changes in Patients Treated
Eva Lonn - McMaster University, Hamilton, Ontario, Canada
Salim Yusuf - McMaster University, Hamilton, Ontario, Canada
The Study to Evaluate Carotid Ultrasound Changes in Patients Treated with Ramipril and Vitamin E (SECURE) is a clinical trial with a 3×2 factorial design based at six centres in Canada and is a substudy of the Heart Outcomes Prevention Evaluation (HOPE) study. The principal aim of the trial was to investigate the effect of Vitamin E (400IU/day) or Ramipril (2.5mg/day) or Ramipril (10mg/day) on atherosclerosis in patients with of high cardiovascular risk. Individuals were eligible for inclusion if they were had vascular disease or diabetes and at least one additional cardiovascular risk factor. All patients provided written, informed consent, and the study protocol was approved by the Research Ethics Board of each participating centre.
Study design and baseline characteristics of the study to evaluate carotid ultrasound changes in patients treated with ramipril and vitamin E: SECURE. Am J Cardiol. 1996 Oct 15;78(8):914-9
Effects of Ramipril and Vitamin E on Atherosclerosis: The Study to Evaluate Carotid Ultrasound Changes in Patients Treated With Ramipril and Vitamin E (SECURE). Circulation. 2001 Feb 20;103(7):919-25