RIS – Risk Factor Intervention Study

Principal contacts

Stefan Agewall - University of Oslo, Oslo, Norway

Caroline Schmidt - University of Gothenburg, Gothenburg, Sweden

Study design

The Risk Factor Intervention Study (RIS) is a two-arm clinical trial based at the Hypertension Unit at the University hospital in Gothenburg, Sweden. The principal aim of the trial was to investigate the effect of usual care versus intervention (usual care and obtain a serum concentration of total cholesterol below 6.0mmol/L, to help current smokers to quit, to discourage non-smoking patients from starting to smoke, and to reduce the HbA1c level below 6.0% in diabetic patients) on intima-media thickness and cardiovascular events in high risk hypertensive men. Men were eligible for inclusion if they were aged between 50 and 72 years with treated primary hypertension and with one or more of the following: hypercholesterolaemia, tobacco smoking, or diabetes mellitus. All patients gave informed consent and the study was approved by the Ethical Committee of Gothenburg University.


Key publications

Ultrasound Evaluation of Atherosclerotic Manifestations in the Carotid Artery in High-Risk Hypertensive Patients. Arterioscler Thromb. 1994 Aug;14(8):1297-304

Does microalbuminuria predict cardiovascular events in nondiabetic men with treated hypertension? Risk Factor Intervention Study Group. Am J Hypertens. 1995 Apr;8(4 Pt 1):337-42

Multiple Risk Intervention in High-Risk Hypertensive Patients: A 3-Year Ultrasound Study of Intima-Media Thickness and Plaques in the Carotid Artery. Arterioscler Thromb Vasc Biol. 1996 Mar;16(3):462-70

Negative Feelings (Discontent) Predict Progress of Intima-Media Thickness of the Common Carotid Artery in Treated Hypertensive Men at High Cardiovascular Risk. Am J Hypertens. 1996 Jun;9(6):545-50

Multiple risk intervention trial in high risk hypertensive men: comparison of ultrasound intima-media thickness and clinical outcome during 6 years of follow-up. J Intern Med. 2001 Apr;249(4):305-14