PLIC  – Presence and Progression of Lesions in Carotid Arteries Study

Principal contacts

Alberico Catapano - University of Milan, Milan, Italy

Liliana Grigore - Bassini Hospital, Cinisello Balsamo, Italy

Giuseppe D. Norata - Bassini Hospital, Cinisello Balsamo, Italy

Study design

The Presence and Progression of Lesions in Carotid Arteries Study (PLIC) is a general population study based in Milan, Italy. Ambulatory patients of the Atherosclerosis Center in Bassini Hospital, Department of Pharmacological Sciences (University of Milan, Italy), were enrolled in this study. Exclusion criteria were use of hypolipidemic drugs, presence of liver or kidney disease, and thyroid dysfunction. The principal aim of the PLIC Study was to investigate the presence and progression of atherosclerotic lesions and carotid intima-media thickness as well as the association between cardiovascular risk factors and carotid intima-media thickness. The study was approved by the Ethics Committee of the University of Study of Milan, all participants signed a written informed consent.


Key publications

Effect of the Toll-like receptor 4 (TLR-4) variants on intima-media thickness and monocyte-derived macrophage response to LPS. J Intern Med. 2005 Jul;258(1):21-7

Effects of Fractalkine Receptor Variants on Common Carotid Artery Intima-Media Thickness. Stroke. 2006 Jun;37(6):1558-61

Leptin:Adiponectin Ratio Is an Independent Predictor of Intima Media Thickness of the Common Carotid Artery. Stroke. 2007 Oct;38(10):2844-6

IDOL N342S Variant, Atherosclerosis Progression and Cardiovascular Disorders in the Italian General Population. PLoS One. 2015 Apr 30;10(4):e0122414