PERIOCARDIO – PerioCardio Study

Principal contacts

Kostas Kapellas - University of Adelaide, Adelaide, SA, Australia

Lisa M. Jamieson - University of Adelaide, Adelaide, SA, Australia

Michael Skilton - University of Sydney, Sydney, NSW 2006, Australia

Study design

The PerioCardio Study is a two-arm clinical trial based in Australia. The principal aim of the trial was to investigate the effect of intervention (untimed single-visit full-mouth nonsurgical removal of sub and supragingival calculus and plaque biofilm) versus control on cardiovascular surrogate endpoints in an adult indigenous population with moderate/severe periodontal disease. Individuals were eligible for inclusion if they were aboriginal Australian, aged 18 years or older with periodontitis and without a previous history of cardiovascular disease. The study was approved by the Human Research Ethics Committee of the Northern Territory Department of Health and Menzies School of Health Research, the Central Australian Human Research Ethics Committee, Northern Territory Correctional Services Research Committee, University of Adelaide Human Research Ethics Committee, and the Aboriginal Health Council of South Australia. Study participants gave informed consent before participating.

Link to study webpage –


Key publications

The effect of a periodontal intervention on cardiovascular risk markers in Indigenous Australians with periodontal disease: the PerioCardio study. BMC Public Health. 2011 Sep 26;11:729

Effect of Periodontal Therapy on Arterial Structure and Function Among Aboriginal Australians: A Randomized, Controlled Trial. Hypertension. 2014 Oct;64(4):702-8

Periodontal therapy and glycaemic control among individuals with type 2 diabetes: reflections from the PerioCardio study. Int J Dent Hyg. 2017 Nov;15(4):e42-e51