NOMAS-INVEST – Northern Manhattan Study – The Oral Infections and Vascular Disease Epidemiology Study
Tatjana Rundek - University of Miami Miller School of Medicine, Miami, USA
Moise Desvarieux - Mailman School of Public Health, Columbia University, New York, USA
The Oral Infections and Vascular Disease Epidemiology Study (INVEST) is a substudy of the Northern Manhattan Study (NOMAS) based in northern Manhattan, USA. Individuals were eligible for inclusion if they had never been diagnosed with ischaemic stroke, were older than 40 years, and were residents of northern Manhattan for ≥3 months. The principal aim of INVEST was investigating whether periodontal infections lead to increased progression of atherosclerosis and incidence of cardiovascular events. The study was approved by the Institutional Review boards, and all subjects granted informed consent.
Relationship Between Periodontal Disease, Tooth Loss, and Carotid Artery Plaque: The Oral Infections and Vascular Disease Epidemiology Study (INVEST). Stroke. 2003 Sep;34(9):2120-5
Periodontal Microbiota and Carotid Intima-Media Thickness: The Oral Infections and Vascular Disease Epidemiology Study (INVEST). Circulation. 2005 Feb 8;111(5):576-82
Traditional risk factors are not major contributors to the variance in carotid intima-media thickness. Stroke. 2013 Aug;44(8):2101-8