FACIT – Folic Acid and Carotid Intima-media Thickness Study

Principal contacts

Michiel L. Bots - University Medical Center Utrecht, Utrecht, the Netherlands

Study design

The Folic Acid and Carotid Intima-media Thickness Study (FACIT) is a two-arm clinical trial based in Wageningen, the Netherlands. The principal aim of the trial was to investigate the effect of Folic Acid (800μg/day) versus placebo on atherosclerosis, cognitive performance, and hearing. Individuals were recruited via municipal and blood-bank registries. Men and post-menopausal women from the Gelderland region in the Netherlands were eligible for inclusion if they were aged between 50 and 70 years. Women with a surgically removed uterus were required to be older or equal to 55 years. The Wageningen University medical ethics committee approved the study and participants gave written informed consent.

Link to study webpage – https://clinicaltrials.gov/ct2/show/NCT00110604


Key publications

Eff ect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet. 2007 Jan 20;369(9557):208-16

Effect of 3 y of folic acid supplementation on the progression of carotid intima-media thickness and carotid arterial stiffness in older adults. Am J Clin Nutr. 2011 May;93(5):941-9