CHS – Cardiovascular Health Study

Principal contacts

Study data were obtained from BioLINCC.

Study design

The Cardiovascular Health Study (CHS) is a general population study based in four field centres: University of California, Davis, Sacramento County, Sacramento, CA; Johns Hopkins University, Washington County, Hagerstown, MD; Wake Forest University School of Medicine, Forsyth County, Winston-Salem, NC; and University of Pittsburgh, Pittsburgh, PA. Initially, recruitment was conducted between 1989 and 1990. Afterwards, between 1992 and 1993, an additional African American cohort was recruited. Individuals ≥65 years of age were sampled from Medicare lists. The principal aim of the study was to study coronary heart disease and stroke. The study was approved by institutional review committees at the participating sites, and all participants provided written informed consent. Study data were obtained from BioLINCC.

Link to study webpage –



The Cardiovascular Health Study has been supported by the contracts HHSN268201200036C, HHSN268200800007C, HHSN268201800001C, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086, and the grants U01HL080295 and U01HL130114 from the National Heart, Lung, and Blood Institute (NHLBI), with additional contribution from the National Institute of Neurological Disorders and Stroke (NINDS). Additional support was provided by R01AG023629 from the National Institute on Aging (NIA). A full list of principal CHS investigators and institutions can be found at the study’s website.


Key publications

Use of Sonography to Evaluate Carotid Atherosclerosis in the Elderly: The Cardiovascular Health Study. Stroke. 1991 Sep;22(9):1155-63

What Do Carotid Intima-Media Thickness and Plaque Add to Prediction of Stroke and Cardiovascular Disease Risk in Older Adults? The Cardiovascular Health Study. J Am Soc Echocardiogr. 2014 Sep;27(9):998-1005.e2

Years of Able Life in Older Persons—The Role of Cardiovascular Imaging and Biomarkers: The Cardiovascular Health Study. J Am Heart Assoc. 2015 Apr 23;4(4)

The Study of Cardiovascular Health Outcomes in the Era of Claims Data: The Cardiovascular Health Study. Circulation. 2016 Jan 12;133(2):156-64