AIR – Atherosclerosis and Insulin Resistance Study

Principal contacts

Caroline Schmidt - University of Gothenburg, Gothenburg, Sweden

Göran Bergström - University of Gothenburg, Gothenburg, Sweden

Lena Bokemark - Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden

Study design

The Atherosclerosis and Insulin Resistance Study (AIR) is a general population study based in Gothenburg, Sweden. Male individuals at the age of 58 listed in the county council register of Gothenburg were contacted and recruited between 1995 and 1997. Inclusion criteria were 58 years of age, Swedish ancestry, and living in Gothenburg, Sweden. Individuals were excluded if they had cardiovascular or other clinically overt diseases (e.g., malignancy or psychiatric disease) and were on continuous medication with cardiovascular drugs (i.e., antidiabetic, lipid-lowering, antihypertensive, and heart failure drugs or drugs for angina pectoris). The principal aim of the study was to investigate the development of atherosclerosis in men with different degrees of insulin resistance. All men received both written and oral information before consenting to participate in the study. The study was approved by the ethics committee at Sahlgrenska University Hospital.

Link to study webpage – https://medicine.gu.se/english/mkm/investigators/bergstrom/main_research/air

 

Key publications

The Metabolic Syndrome, LDL Particle Size, and Atherosclerosis: The Atherosclerosis and Insulin Resistance (AIR) Study. Arterioscler Thromb Vasc Biol. 2000 Sep;20(9):2140-7

Insulin resistance and intima–media thickness in the carotid and femoral arteries of clinically healthy 58‐year‐old men. The Atherosclerosis and Insulin Resistance Study (AIR). J Intern Med. 2001 Jan; 249(1): 59-67

Insulin, insulin propeptides and intima-media thickness in the carotid artery in 58-year-old clinically healthy men. The Atherosclerosis and Insulin Resistance study (AIR). Diabet Med. 2002 Feb;19(2):144-51