ACAPS – Asymptomatic Carotid Artery Progression Study

Principal contacts

Mark A. Espeland - Wake Forest School of Medicine, Winston-Salem, NC, USA

Study design

The Asymptomatic Carotid Artery Progression Study (ACAPS) is a clinical trial with a 2×2 factorial design based at four clinical centres at academic institutions including the Bowman Gray School of Medicine and the universities of Iowa, Kentucky, and Tennessee. The principal aim of the trial was to investigate the effect of Lovastatin (10-40mg/day) or Warfarin (1g/day) on early carotid atherosclerosis. Individuals were eligible for inclusion if they were free of clinical coronary disease and had LDL-cholesterol values between 130 and 189mg/dL. All clinical centres obtained written informed consent of the included participants.

Link to study webpage –



National Heart, Lung, and Blood Institute (NHLBI)


Key publications

Rationale and Design for the Asymptomatic Carotid Artery Plaque Study (ACAPS). Control Clin Trials. 1992 Aug;13(4):293-314

Effect of Lovastatin on Early Carotid Atherosclerosis and Cardiovascular Events. Circulation. 1994 Oct;90(4):1679-87

Effects of Lovastatin and Warfarin on Early Carotid Atherosclerosis: Sex-Specific Analyses. Circulation. 1999 Jul 20;100(3):e14-7